The majority of our research studies fall into two broad categories: 1) basic science studies designed to answer questions about behavioral and neural changes in cognitive control and emotion regulation resulting as a function of age or disease, and 2) applied studies that utilize the knowledge of the fundamental studies to then target these cognitive control and emotion regulation capacities through mind-body approaches.
UNDERSTANDING CHANGES IN NEUROPSYCHOLOGICAL FUNCTIONING
In our basic science studies, our goal is to comprehensively and rigorously characterize the nature of cognitive and affective changes we see in clinical populations. Traditional neuropsychological assessments are limited in their scope, but by combining advances in neuroimaging research with computational modeling, we aim to systematically parse the contributions of different parameters underlying the specific cognitive mechanism. Additionally, several of our studies employ graph theory metrics to identify dynamic neural connections that predict neuropsychological performance.
MIND-BODY APPROACHES FOR NEUROPSYCHOLOGICAL REHABILITATION
In our intervention studies, we aim to systematically assess the efficacy of various lifestyle and mind-body approaches, in improving cognitive functioning and emotion dysregulation. Using the cognitive and neural parameters from our basic science studies as surrogate endpoints, we investigate whether mind-body interventions, like mindfulness meditation, exercise, tai chi, benefit cognitive and affective functioning.
Preprints (** indicates mentored graduate student; * indicates mentored undergraduate student/research assistant)
Prakash, R.S., McKenna, M.R**., Gbadeyan, O. +, Shankar, R.**, Andridge, R., Scharre, D.W. (under review). A whole-brain functional connectivity model of Alzheimer’s disease pathology. Neurology. Preprint DOI: https://doi.org/10.1101/2021.01.13.21249597.
Prakash, R.S., McKenna, M.R.**, Gbadeyan, O. +, Andridge, R.**, Scharre, D.W. (under review). p-tau/Aβ42 Ratio and Cognitive Decline across the Spectrum of Alzheimer’s Disease. Journal of Alzheimer’s Disease. Preprint DOI:
Manglani, H.**, Fountain-Zaragoza, S.**, Shankar, A.**, Nicholas, J., & Prakash, R.S. (under review). Employing connectome-based models to predict working memory in multiple sclerosis. Brain Connectivity. Preprint DOI:
Fountain-Zaragoza, S.**, Manglani, H.**, Rosenberg, M. D., Andridge, R., & Prakash, R.S. (under review). Defining a connectome-based predictive model of attentional control in aging. Human Brain Mapping. Preprint DOI:
Samimy, S.**, Manglani, H.**, Fountain-Zaragoza, S.**, Andridge, R., & Prakash, R.S. (under review). Impact of Mindfulness Training on In-the-Moment Attentional Control and Emotion Dysregulation in Older Adults: Secondary Analysis of a Pilot, Placebo-Controlled Randomized Controlled Trial. Mindfulness. Preprint DOI: 10.31231/osf.io/rzskp
Peer-Reviewed Publications (** indicates mentored graduate student; * indicates mentored undergraduate student/research assistant)
Schirda, B.*, Duraney, E.*, Lee, K., Manglani, H., Andridge, R., Plate, A., Nicholas, J., & Prakash, R.S.(2020). Mindfulness Training and Emotion Dysregulation in Multiple Sclerosis: A Pilot Randomized Controlled Trial. Rehabilitation Psychology, 65(3), 206-218. doi:10.1037/rep0000324.
Manglani, H.*, Samimy, S.*, Schirda, B.*, Nicholas, J.A., & Prakash, R.S. (2020). Does 4 Weeks of Cognitive Rehabilitation Improve Processing Speed and Working Memory in MS? Results of Mindfulness Training Vs. Adaptive Computerized Training. Neuropsychology, 34(5), 591-604. doi:10.1037/neu0000633.
Whitmoyer, P.*, Fountain-Zaragoza, S.*, Andridge, R., Bredemeier, K., Londerée , A.** Kaye, L., Prakash, R.S. (2020). Mindfulness Training and Attentional Control in Older Adults: A Randomized Controlled Trial. Mindfulness, 11, 203-218. doi:10.1007/s12671-019-01218-3.
Prakash, R.S., Schirda, B.*, Valentine, T., Crotty, M.**, & Nicholas, J. (2019). Emotion Dysregulation in Multiple Sclerosis: Impact on Symptoms of Depression & Anxiety. Multiple Sclerosis & Related Disorders, 36, 1-7. doi:10.1016/j.msard.2019.101399.
Fountain-Zaragoza, S.*, Samimy, S.*, Rosenberg, M., & Prakash, R.S. (2019). Connectome-Based Models Predict Attentional Control in Aging Adults. NeuroImage. 186, 1-13. doi:10.1016/j.neuroimage.2018.10.074.